Encapsulating cannabinoids in lipid-based nanoparticles - Part 2: THC vs. CBD

Ascension Sciences’ innovative research results featured once again on Pharma Excipients! This review compares the nanoparticle formulation of THC vs. CBD. Carried out by two of our scientists, Andrea Olaizola and Behnoush Kermanshahi, which investigated the encapsulation efficiency, stability and drug retention of each nanoparticle. Check out the results below.

Encapsulating cannabinoids in lipid-based nanoparticles - Part 1: CBD vs. CBDA

Ascension Sciences is proud to have its innovative research results featured on Pharma Excipients, developed and written by two of our scientists Andrea Olaizola and Behnoush Kermanshahi. We are optimizing our nanoparticle formulations for a variety of cannabinoids. In this review we compare nanoparticle formulations to encapsulate CBD and CBDA. Check out the results below.

Therapeutic Targets for Cannabinoids

The term medical cannabis refers to the use of cannabis to treat diseases or reduce symptoms. Cannabis has been shown to be beneficial in treating many complex diseases or rare conditions where there is no effective treatment, and when incumbent methods have detrimental side effects. Examples where medical cannabis has gained attention in the last years are multiple sclerosis and central sensitivity syndromes like migraines, and neuropathic pain. 

Effects of Concentrating Cannabinoid Loaded Liposome Formulations

Phytocannabinoids have been increasingly used as therapeutics in recent years. Lipid nanoparticles are effective vehicles for hydrophobic bioactive compounds and show strong potential for cannabinoid delivery.

How to Develop Quality Cannabis Products with Advanced Analytical Testing

A thorough cannabis product development process goes far beyond extracting and packaging. In this piece, Complex Biotech Discovery Ventures’ Vanessa Clarke and Ascension Sciences’ Melody Lin detail four key stages in the product development lifecycle, from flower to consumption.

Analysis of Commercially Available Cannabis Products for Recreational Purposes

For one month, we monitored three cannabinoid recreational samples (in the form of beverage, powder & drops) to determine their shelf life stability. Here’s what we found.

Cannabis Compliance Testing: Safety vs. Quality

In this Q&A, we hear from Dr. Markus Roggen and Tomas Skrinskas as they provide their take on the challenges facing the industry’s compliance testing standards as well as some opportunities in advanced analytical chemistry.

Biosynthesis of Cannabinoids

What are cannabinoids, and what is the biosynthesis process of these particles? Review the poster to learn more about diphenol + alkyl chains, monoterpenes, CBGA and cannabinoid biosynthesis enzymes.

Snapshot Analysis: Nano-emulsification Formulation Technology

Nanoemulsions have a variety of applications in research and development, as well as everyday life. Optimizing size and stability is key to creating effective therapeutic nanoemulsion delivery systems, which is achieved through tailored formulation development.

Impact of Lipid Composition on Liposome Stability & Cannabinoid Drug Encapsulation Efficiency

Recent literature increasingly supports the therapeutic use of cannabinoids. They have been shown to be beneficial in the treatment of chronic pain, nausea and seizures. Lipid nanoparticles offer an effective alternative to improve pharmacokinetic and biodistribution profiles of drug payloads.

Impact of Lipid Composition on Liposome Stability & Cannabinoid Drug Encapsulation Efficiency

Cannabinoids have been shown to be beneficial in the treatment of various diseases such as Alzheimer’s disease and multiple sclerosis. However, such benefits are hindered by their poor aqueous solubility, limiting bioavailability. Lipid nanoparticles offer an effective alternative.

Phytocannabinoids vs Endocannabinoids

Did you know that our body produces its own type of cannabinoids? View the infographic for a comparison of phyto- and endocannabinoids.

Daily Applications of Lipid Nanoparticles

Lipid nanoparticles have a wide range of applications in various industries. Review the poster to learn more about how nanoparticles are used in antibiotic delivery, diagnostics, cosmetics and more.

Glossary: Nanoparticle Types, Applications & Characterization Parameters

Too often, there are misunderstandings and questioning of results across studies simply because terms are not being used in the same manner to describe the same process. Here are definitions of commonly used terms used to describe NP types and applications.

Introduction to Polymer Nanoparticles for Drug Delivery

For drug delivery, there are different types of biocompatible polymers used in the pharmaceutical industry to make NPs. Finding the balance between hydrophilic and hydrophobic is key to accomplish an efficient therapeutic polymer NP carrier.

Introduction to Nanoemulsions

Nanoemulsion technology is the future of cannabis formulations. Using a variety of techniques, each with their own advantages, allows for the creation of products not seen on the market today. Here are the three primary motivations for using nano formulations.

Preparation of Cannabinoid-Loaded Liposomes Using Microfluidics

There are more than 100 cannabinoids that have been isolated from cannabis. CBD, THC and CBN are the most frequently studied species. Here, we report microfluidic assembly of THC- and CBD-loaded liposomes using the NanoAssemblr Benchtop instrument. 

The Effects of Storage Conditions on Cannabinoid Stability

Monitoring the cannabinoid composition of the extracts and purity of the isolated compounds is important to ensure the potency of prepared formulations as well as proper sample handling in the laboratory.

Biocompatibility of Common Nanoparticle Excipients

Because of their submicroscopic size, nanoparticles have unique material characteristics, and manufactured nanoparticles may find practical applications in a variety of areas.

Aqueous Phase Effect on Nanoemulsion Properties – Choose Your Media Wisely!

Cannabinoids have a very low solubility in water. They can, however, be formulated to be water compatible and appear water soluble. One type of such a formulation is nanoemulsion.

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